This is especially important if your pet is currently taking probenecid. [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. Clin Infect Dis. Some side effects may not be reported. COPD Study Group." However, many people have no side effects or only have minor side effects. Diarrhea. J Antimicrob Chemother 24(suppl a (1989): 311-20, 12. All drugs may cause side effects. Demographic data are included in Table Meropenem Study Group." CPT Pharmacometrics Syst Pharmacol. The pharmacokinetic parameter … doi: 10.1371/journal.pcbi.1007117. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. eCollection 2019 Jun. Meropenem. Find patient medical information for Meropenem Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ralph ED, John M, Rieder MJ, Bombassaro AM "Serum Sickness-like Reaction Possibly Associated with Meropenem Use." Last updated on Jul 26, 2020. COVID-19 is an emerging, rapidly evolving situation. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. You may report side effects to Health Canada at 1-866-234-2345. The safety of imipenem/cilastatin has not been established for animals that are pregnant or lactating. Drug information provided by: IBM Micromedex.  |  Category: Veterinary. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. Am J Health Syst Pharm 69 (2012): 1109, 19. Description and Brand Names. Epub 2016 Aug 27. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Zhanel GG, Wiebe R, Dilay L, et al. Side Effects; Products and services. This site needs JavaScript to work properly. 2016. Clin Infect Dis 24 Suppl 2 (1997): s197-206, 7. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. You may need medical attention if you get some of the side effects. Upset stomach or throwing up. In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often. Infection 24 (1996): 480-4, 10. O 0, 3. Meropenem - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Video Medindia Clipboard, Search History, and several other advanced features are temporarily unavailable. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Medically reviewed by Drugs.com. "Comparative Review of the Carbapenems." Sepúlveda RA, Downey P, Soto D, Wong KY, Leung YC, So LY, Andresen M. Biomed Res Int. [Ref], Common (1% to 10%): Anemia, hypochromic anemia, bleeding events (including gastrointestinal hemorrhage, melena, epistaxis, hemoperitoneum), thrombocythemia, Uncommon (0.1% to 1%): Increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cells, decreased prothrombin time, decreased partial thromboplastin time, leukocytosis, eosinophilia, thrombocytopenia, leukopenia, neutropenia, Postmarketing reports: Agranulocytosis, positive Coombs test (direct or indirect), hemolytic anemia[Ref], Shock occurred more often in patients with moderately severe renal dysfunction. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." Carbapenem resistance is a growing problem in human medicine and is expecte… The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. Storage of the Drug. Therapeutic Effects: Bactericidal action against susceptible bacteria. Cats are very susceptible to the vestibular effects of amikacin. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating Meropenem Updated September 2016 Meropenem is a semi-synthetic -lactam antibiotic that belongs in the penicillin-based group of drugs called carbapenems. Meropenem (Merrem) use in cats, is it safe? Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. Merrem (meropenem)." The pharmacology of meropenem, a new carbapenem antibiotic. 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